Molecular Traceback

As viruses evolve they accumulate mutations in their genomes. These mutations can be used within a framework to estimate their historic pathways and allow us to understand how they spread over the population.

Some publications that we have been engaged with molecular traceback

- Paraskevis D, Magiorkinis G, Magiorkinis E, Ho SYW, Belshaw R, Allain J-P, Hatzakis A. Dating the origin and dispersal of Hepatitis B Virus infection in humans and primates. Hepatology In press

- Magiorkinis G. A novel Bunyavirus in China. New England Journal of Medicine 365:864

- Magiorkinis G, Magiorkinis E, Paraskevis D, Ho SY, Shapiro B, Pybus OG, Allain JP,  Hatzakis A. The global spread of hepatitis C virus 1a and 1b: a phylodynamic and phylogeographic analysis. PLoS Medicine 6:e1000198

- Paraskevis D, Pybus O, Magiorkinis G, Hatzakis A, Wensing AM, van de Vijver DA, Albert J, Angarano G et al. Tracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach. Retrovirology 6:49

- Paraskevis D, Magiorkinis E, Magiorkinis G, Sypsa V, Paparizos V, Lazanas M, Gargalianos P et al. Increasing prevalence of HIV-1 subtype A in Greece estimating: epidemic history and origin. Journal of Infectious Diseases 196:1167-76

- Paraskevis D, Magiorkinis E, Magiorkinis G, Kiosses VG, Lemey P, Vandamme AM, Rambaut A, Hatzakis A. Phylogenetic reconstruction of a known HIV-1 CRF04_cpx transmission network using maximum likelihood and Bayesian methods. Journal of Molecular Evolution 59:709-17